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Randall-Selitto痛覺測試儀簡單介紹
Randall-Selitto痛覺測試儀適用于大小鼠機械痛耐受檢測,設備覆蓋學科包括神經(jīng)生物學、神經(jīng)藥理學、神經(jīng)病學、麻醉科學、康復科學和中西醫(yī)結合學科。
?Randall-Selitto痛覺測試儀 的詳細介紹 產(chǎn)品品牌:意大利UGO 產(chǎn)品型號:37215
Randall-Selitto痛覺測試儀根據(jù)Randall-Selitto理論設計,是進行壓爪實驗的經(jīng)典儀器。實驗時,將嚙齒類動物的爪置于圓柱形底座,操作員踩壓腳踏板,其上方的圓錐形推進器往爪上施力。當受試動物開始掙扎時,操作員松開腳踏板板,讀取刻度值,其表示受試動物的疼痛值。壓痛儀的顯著特征是配備了一個低電壓同步電動機。
該實驗常用于止痛藥和消炎藥的快速篩選。
特Randall-Selitto痛覺測試儀征
基于力學原理的壓力增強設計
持久可靠,不需校準
雙面壓力頭 (鈍、錐形)
優(yōu)點
壓力增強范圍大 (0-750 g)
可用于發(fā)炎和非發(fā)炎的爪
用于不同實驗
產(chǎn)品規(guī)格:
**力值:750 g
力增加速率:16 g/s (加一個砝碼時為16x2 g/s, 加兩個砝碼時為16x3g/s)
刻度分辨率:5 g (加一個砝碼時為5x2g, 加兩個砝碼時為5x3g)
電源要求:115或230V,50/60 Hz,**15 W
參考文獻:
關于方法
· L.O. Randall and J.J. Selitto: “A Method for Measurement of Analgesic Activity on Inflamed Tissue” Arch. Int. Pharmacodyn. CXI, No. 4: 409-419, 1957.
涉及壓痛儀(大鼠)
· K. Walker et alia: “The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain“ J. Pharmacol. Exper. Therap. 304, No. 1: 56-62, 2003.
· S. Asfaha et alia: “Proteinase-Activated Receptor-1 Agonists attenuate nociception in Response to Noxious Stimuli“ Br. J. Pharmacol. 135: 1101-1106, 2002.
· K.O. Aley et alia: “Chronic Hypersensitivity for Inflammatory Nociceptor sensitization Mediated by the ?Isozyme of Protein Kinase C“ J. Neuroscience 20 (12): 4680-4685, 2000.
· O.A. Kochuvelikakam and J.D. Levine: “Role of Protein Kinase A in the Maintenance of Inflammatory Pain“ J. Neuroscience. 19(6): 2181-2186, 1999.
涉及壓痛儀(小鼠)
· H. Saegusa et alia: “Suppression of Inflammatory and Neuropathic Pain Symptoms in Mice Lacking the N-type Ca2+ Channel“ The EMBO Journal. 20, No. 10: 2349-2356, 2001.
· W. Binder et alia: “Effect of Gender on Anti-Inflammatory and Analgesic Actions of Two К-Opioids“ J. Pharmacol. Exper. Therap. 292: 303-309, 2000.